Effects of [5-(2-Methoxy-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32560), a Novel Sodium/Hydrogen Exchanger-1 Inhibitor, on Myocardial Infarct Size and Ventricular Arrhythmias in a Rat Model of Ischemia/Reperfusion Heart Injury

• Main Authors: Jung-Woo Park (Author), Hui-Yul Roh (Author), In-Sang Jung (Author), Yeo-Pyo Yun (Author), Kyu-Yang Yi (Author), Sung-Eun Yoo (Author), Suk-Hyung Kwon (Author), Hun-Jong Chung (Author), Hwa-Sup Shin (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cardioprotective effects of the novel sodium/hydrogen exchanger-1 (NHE-1) inhibitor KR-32560 {[5-(2-methoxy-5-fluorophenyl)furan-2-ylcarbonyl]guanidine} were studied in an anesthetized rat model of 30-min ischemia / 2.5-h reperfusion heart injury. KR-32560 (0.01 - 1 µM) dose-dependently inhibite...