Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes

• Main Authors: Shuang Liang (Author), Zheng-tao Lv (Author), Jia-ming Zhang (Author), Yu-ting Wang (Author), Yong-hui Dong (Author), Zheng-gang Wang (Author), Kun Chen (Author), Peng Cheng (Author), Qing Yang (Author), Feng-jing Guo (Author), Wei-wei Lu (Author), Wen-tao Zhu (Author), An-min Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibits phosphorylation of RIPK1. RIPK1 regulates inflammation and cell death by interacting with receptor-interacting serine/threonine protein kinases 3(RIPK3). We hypoth...