Flurbiprofen inhibits heme induced NLRP3 inflammasome in Berkeley sickle cell disease mice

• Main Authors: Dilpreet Kour (Author), Mehboob Ali (Author), Parul Khajuria (Author), Kuhu Sharma (Author), Palash Ghosh (Author), Sukhleen Kaur (Author), Surbhi Mahajan (Author), P. Ramajayan (Author), Sonali S. Bharate (Author), Subhash Bhardwaj (Author), Sanghapal D. Sawant (Author), D. Srinivasa Reddy (Author), Ajay Kumar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sickle cell disease (SCD) is accompanied by several complications, which emanate from the sickling of erythrocytes due to a point mutation in the β-globin chain of hemoglobin. Sickled erythrocytes are unable to move smoothly through small blood capillaries and therefore, cause vaso occlusion and sev...