Paracetamol inhibits Ca2+ permeant ion channels and Ca2+ sensitization resulting in relaxation of precontracted airway smooth muscle

• Main Authors: Yuan-Yuan Chen (Author), Meng-Fei Yu (Author), Xiao-Xue Zhao (Author), Jinhua Shen (Author), Yong-Bo Peng (Author), Ping Zhao (Author), Lu Xue (Author), Weiwei Chen (Author), Li-Qun Ma (Author), Gangjian Qin (Author), Jiapei Dai (Author), Qing-Hua Liu (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to screen a bronchodilator from old drugs and elucidate the underlying mechanism. Paracetamol (acetaminophen) is a widely used analgesic and antipyretic drug. It has been reported that it inhibits the generation of prostaglandin and histamine, which play roles in asthma...