Paracetamol inhibits Ca2+ permeant ion channels and Ca2+ sensitization resulting in relaxation of precontracted airway smooth muscle

• Príomhchruthaitheoirí: Yuan-Yuan Chen (Údar), Meng-Fei Yu (Údar), Xiao-Xue Zhao (Údar), Jinhua Shen (Údar), Yong-Bo Peng (Údar), Ping Zhao (Údar), Lu Xue (Údar), Weiwei Chen (Údar), Li-Qun Ma (Údar), Gangjian Qin (Údar), Jiapei Dai (Údar), Qing-Hua Liu (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Elsevier, 2020-02-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

The purpose of this study was to screen a bronchodilator from old drugs and elucidate the underlying mechanism. Paracetamol (acetaminophen) is a widely used analgesic and antipyretic drug. It has been reported that it inhibits the generation of prostaglandin and histamine, which play roles in asthma...