Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives

• Główni autorzy: Rosaria Gitto (Autor), Laura De Luca (Autor), Francesca Mancuso (Autor), Sonia Del Prete (Autor), Daniela Vullo (Autor), Claudiu T. Supuran (Autor), Clemente Capasso (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki values were compared to those of selected human CA isoforms (...