Early life phenobarbital exposure dysregulates the hippocampal transcriptome

• Hoofdauteurs: Seán Quinlan (Auteur), Tahiyana Khan (Auteur), David McFall (Auteur), Carolina Campos-Rodriguez (Auteur), Patrick A. Forcelli (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Introduction: Phenobarbital (PB) and levetiracetam (LEV) are the first-line therapies for neonates with diagnosed seizures, however, a growing body of evidence shows that these drugs given during critical developmental windows trigger lasting molecular changes in the brain. While the targets and mec...