Early life phenobarbital exposure dysregulates the hippocampal transcriptome

• Prif Awduron: Seán Quinlan (Awdur), Tahiyana Khan (Awdur), David McFall (Awdur), Carolina Campos-Rodriguez (Awdur), Patrick A. Forcelli (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Introduction: Phenobarbital (PB) and levetiracetam (LEV) are the first-line therapies for neonates with diagnosed seizures, however, a growing body of evidence shows that these drugs given during critical developmental windows trigger lasting molecular changes in the brain. While the targets and mec...