Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

• Hauptverfasser: Jiayi Huang (Verfasst von), Shiqi Hong (Verfasst von), Lucas Yuan Hao Goh (Verfasst von), Hailong Zhang (Verfasst von), Tao Peng (Verfasst von), Keat Theng Chow (Verfasst von), Rajeev Gokhale (Verfasst von), Vinod Tuliani (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2024-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE^® HPβCD (hydroxypropyl beta-cyclodextrin) has funct...