Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis

• Main Authors: Abdulbasit Amin (Author), Marina Badenes (Author), Johanna Tüshaus (Author), Érika de Carvalho (Author), Emma Burbridge (Author), Pedro Faísca (Author), Květa Trávníčková (Author), André Barros (Author), Stefania Carobbio (Author), Pedro M. Domingos (Author), Antonio Vidal-Puig (Author), Luís F. Moita (Author), Sarah Maguire (Author), Kvido Stříšovský (Author), Francisco J. Ortega (Author), José Manuel Fernández-Real (Author), Stefan F. Lichtenthaler (Author), Colin Adrain (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling molecules from the cell surface. Although its importance for the immune system and epithelial tissues is well-documented, little is known about the role of ADAM17 in metabolic ho...