Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID‐19, in Healthy Subjects

• Main Authors: Rita Humeniuk (Author), Anita Mathias (Author), Huyen Cao (Author), Anu Osinusi (Author), Gong Shen (Author), Estelle Chng (Author), John Ling (Author), Amanda Vu (Author), Polina German (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Remdesivir (RDV), a single diastereomeric monophosphoramidate prodrug that inhibits viral RNA polymerases, has potent in vitro antiviral activity against severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). RDV received the US Food and Drug Administration (FDA)'s emergency use authoriz...