Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data

• Main Authors: Albert Martínez-Pinteño (Author), Patricia Gassó (Author), Llucia Prohens (Author), Alex G. Segura (Author), Mara Parellada (Author), Jerónimo Saiz-Ruiz (Author), Manuel J. Cuesta (Author), Miguel Bernardo (Author), Amalia Lafuente (Author), Sergi Mas (Author), Natalia Rodríguez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antipsychotics (APs) are associated with weight gain and other metabolic abnormalities such as hyperglycemia, dyslipidemia and metabolic syndrome. This translational study aimed to uncover the underlying molecular mechanisms and identify the key genes involved in AP-induced metabolic effects. An int...