Effect of Terpenes on the Skin Permeation of Lomerizine Dihydrochloride

• Main Authors: Takayuki Furuishi (Author), Yukiko Kato (Author), Toshiro Fukami (Author), Toyofumi Suzuki (Author), Tomohiro Endo (Author), Hiromasa Nagase (Author), Haruhisa Ueda (Author), Kazuo Tomono (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Lomerizine dihydrochloride (LOM) is a Ca2+ channel blocker used as an antimigraine drug, which is currently administered orally in Japan. We therefore investigated the effect of terpenes in propylene glycol (PG) solvent on the percutaneous absorption of LOM by hairless mouse skin. Methods....