Immunoexpression of PD-L1, CD4+ and CD8+ cell infiltrates and tumor-infiltrating lymphocytes (TILs) in the microenvironment of actinic cheilitis and lower lip squamous cell carcinoma

• Main Authors: Vinícius Gonçalves de Souza (Author), Damilys Joelly Souza Santos (Author), Ana Gabriela Silva (Author), Rosy Iara Maciel de Azambuja Ribeiro (Author), Adriano Mota Loyola (Author), Sérgio Vitorino Cardoso (Author), Carla Silva Siqueira Miranda (Author), Ludimila Paula Vaz Cardoso (Author)
• Format: Book
• Published: University of São Paulo, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Lower lip squamous cell carcinomas (LLSCC) could be associated with a previous history of potentially malignant oral diseases (PMOD), especially actinic cheilitis (AC), with high sun exposure being a well-described risk factor. Immune evasion mechanisms, such as the PD-1/PD-L1 (programmed c...