Targeted proteomics-derived biomarker profile develops a multi-protein classifier in liquid biopsies for early detection of esophageal squamous cell carcinoma from a population-based case-control study

• Main Authors: Xiaorong Yang (Author), Chen Suo (Author), Tongchao Zhang (Author), Xiaolin Yin (Author), Jinyu Man (Author), Ziyu Yuan (Author), Jingru Yu (Author), Li Jin (Author), Xingdong Chen (Author), Ming Lu (Author), Weimin Ye (Author)
• Format: Book
• Published: BMC, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Early diagnosis of esophageal squamous cell carcinoma (ESCC) remains a challenge due to the lack of specific blood biomarkers. We aimed to develop a serum multi-protein signature for the early detection of ESCC. Methods We selected 70 healthy controls, 30 precancerous patients, 6...