Self-Penetrating Oligonucleotide Derivatives: Features of Self-Assembly and Interactions with Serum and Intracellular Proteins

• Main Authors: Irina Bauer (Author), Ekaterina Ilina (Author), Timofey Zharkov (Author), Evgeniya Grigorieva (Author), Olga Chinak (Author), Maxim Kupryushkin (Author), Victor Golyshev (Author), Dmitry Mitin (Author), Alexey Chubarov (Author), Svetlana Khodyreva (Author), Elena Dmitrienko (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipophilic oligonucleotide derivatives are a potent approach to the intracellular delivery of nucleic acids. The binding of these derivatives to serum albumin is a determinant of their fate in the body, as its structure contains several sites of high affinity for hydrophobic compounds. This study fo...