U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo

• Main Authors: Rafal Goraczniak (Author), Brian A Wall (Author), Mark A Behlke (Author), Kim A Lennox (Author), Eric S Ho (Author), Nikolas H Zaphiros (Author), Christopher Jakubowski (Author), Neil R Patel (Author), Steven Zhao (Author), Carlo Magaway (Author), Stacey A Subbie (Author), Lumeng Jenny Yu (Author), Stephanie LaCava (Author), Kenneth R Reuhl (Author), Suzie Chen (Author), Samuel I Gunderson (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

U1 Adaptor is a recently discovered oligonucleotide-based gene-silencing technology with a unique mechanism of action that targets nuclear pre-mRNA processing. U1 Adaptors have two distinct functional domains, both of which must be present on the same oligonucleotide to exert their gene-silencing fu...