An aromatic imidazoline derived from chloroquinoline triggers cell cycle arrest and inhibits with high selectivity the Trypanosoma cruzi mammalian host-cells infection.

• Main Authors: Roberto I Cuevas-Hernández (Author), Richard M B M Girard (Author), Luka Krstulović (Author), Miroslav Bajić (Author), Ariel Mariano Silber (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi is a hemoflagellated parasite causing Chagas disease, which affects 6-8 million people in the Americas. More than one hundred years after the description of this disease, the available drugs for treating the T. cruzi infection remain largely unsatisfactory. Chloroquinoline and aryl...