Cover Image

Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs

We investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram and monophasic action potential (MAP), which was compared with those of halothane or non-inhaled anesthetics ketamine/xylazine. Intravenous...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yoshinobu Nagasawa (Author), Kaori Sakai (Author), Rui Kurimoto (Author), Satoshi Kawakami (Author), Megumi Aimoto (Author), Akira Takahara (Author)
Format:	Book
Published:	Elsevier, 2020-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Electropharmacological profile of an atrial-selective sodium channel blocker acehytisine assessed in the isoflurane-anesthetized guinea-pig model
by: Xin Cao, et al.
Published: (2019)

The Conventional Antihistamine Drug Cyproheptadine Lacks QT-interval-Prolonging Action in Halothane-Anesthetized Guinea Pigs: Comparison With Hydroxyzine
by: Kazuko Kobayashi, et al.
Published: (2014)

Role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in the anesthetized atrioventricular block rabbit
by: Satoshi Kawakami, et al.
Published: (2022)

Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs
by: Akira Takahara, et al.
Published: (2012)

Nitrous oxide improves cardiovascular, respiratory, and thermal stability during prolonged isoflurane anesthesia in juvenile guinea pigs
by: Ryan P. Sixtus, et al.
Published: (2021)

Effects of the Fluoroquinolone Antibacterial Drug Ciprofloxacin on Ventricular Repolarization in the Halothane-Anesthetized Guinea Pig
by: Kazuhiro Matsuo, et al.
Published: (2013)

QT PRODACT: Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles
by: Yoshihide Kii, et al.
Published: (2005)

Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model
by: Satoshi Kawakami, et al.
Published: (2020)

QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals
by: Hiroyuki Tashibu, et al.
Published: (2005)

Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats
by: Yun-Fei Shuai, et al.
Published: (2014)

Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats
by: Yun-Fei Shuai, et al.
Published: (2014)

Physiological role of nitric oxide for regulation of arterial stiffness in anesthetized rabbits
by: Tatsuo Chiba, et al.
Published: (2019)

In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model
by: Mihoko Hagiwara, et al.
Published: (2016)

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation
by: Mayumi Kano, et al.
Published: (2005)

Selectivity of Ca2+ channel blockers for dilator actions on the isolated lower esophageal sphincter and aorta from rats
by: Akira Takahara, et al.
Published: (2018)

Sevoflurane Inhibition of the Slowly Activating Delayed Rectifier K+ Current in Guinea Pig Ventricular Cells
by: Shigehiro Shibata, et al.
Published: (2004)

Concentration-QT Modeling Following Inhalation of the Novel Inhaled Phosphodiesterase‐4 Inhibitor CHF6001 in Healthy Volunteers Shows an Absence of QT Prolongation
by: Koen Jolling, et al.
Published: (2019)

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart
by: Petr Vesely, et al.
Published: (2019)

Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits
by: Kiyoshi Sakuma, et al.
Published: (2019)

Acehytisine suppresses atrial fibrillation in rats with dilated atria caused by chronic volume overload
by: Xin Cao, et al.
Published: (2020)

Influence of chronic volume overload-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria
by: Xin Cao, et al.
Published: (2018)

Analgesic Effects of Sevoflurane and Isoflurane on Elderly Patients with Colon Cancer and Their Influences on Immunity and Postoperative Cognitive Function
by: Mingde YANG, et al.
Published: (2019)

In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs
by: Hiroyuki Saito, et al.
Published: (2021)

Comparison of the effects of two anesthetics, isoflurane and urethane, on bladder function in rats
by: Naoki Aizawa, et al.
Published: (2023)

QT PRODACT: Inter- and Intra-facility Variability of the Action Potential Assay Using Isolated Guinea-Pig Papillary Muscles
by: Ryuzaburo Yamazaki, et al.
Published: (2005)

Signatures of Thalamocortical Alpha Oscillations and Synchronization With Increased Anesthetic Depths Under Isoflurane
by: Jingyao Jiang, et al.
Published: (2022)

Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis
by: Jun-tang Li, et al.
Published: (2013)

Prolonged QT During Epileptic Seizures
by: J Gordon Millichap
Published: (2010)

Prolonged QT Syndrome Presenting as Epilepsy
by: J Gordon Millichap
Published: (1994)

Comparison of hemodynamic response to adrenaline infiltration in children undergoing cleft palate repair during general anesthesia with sevoflurane and isoflurane
by: Poojita Reddy Gunnam, et al.
Published: (2016)

Effect of QT interval-prolonging drugs taken in pregnancy on the neonatal QT interval
by: Holger Michel, et al.
Published: (2023)

QT PRODACT: In Vivo QT Assay in the Conscious Dog for Assessing the Potential for QT Interval Prolongation by Human Pharmaceuticals
by: Shigeki Toyoshima, et al.
Published: (2005)

Comparative study of the potentiating effect of isoflurane and sevoflurane on the duration of muscle relaxation during surgical interventions in one-day surgery in children.
by: E. M. Nasibova
Published: (2021)

QT interval prolongation and with donepezil, rivastigmine and galantamine
by: Katie Malone, et al.
Published: (2020)

QT PRODACT: A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles
by: Seiji Hayashi, et al.
Published: (2005)

QT PRODACT: In Vivo QT Assay With a Conscious Monkey for Assessment of the Potential for Drug-Induced QT Interval Prolongation
by: Kentaro Ando, et al.
Published: (2005)

Halothane Sensitizes the Guinea-Pig Heart to Pharmacological IKr Blockade: Comparison With Urethane Anesthesia
by: Yasue Sakaguchi, et al.
Published: (2005)

Life-Threatening QT Prolongation in a Preterm Infant
by: Christian Paech, et al.
Published: (2014)

CLINICAL SIGNIFICANCE OF DRUGINDUCED INTERVALS QT AND QTC PROLONGATION
by: N. V. Furman, et al.
Published: (2015)

CLINICAL SIGNIFICANCE OF DRUGINDUCED INTERVALS QT AND QTC PROLONGATION
by: N. V. Furman, et al.
Published: (2015)