Differential effects of ketoconazole, fluconazole, and itraconazole on the pharmacokinetics of pyrotinib in vitro and in vivo

• Главные авторы: Li Wang (Автор), Fan Wu (Автор), Jia Xu (Автор), Yu Wang (Автор), Weidong Fei (Автор), Hui Jiang (Автор), Peiwu Geng (Автор), Quan Zhou (Автор), Shuanghu Wang (Автор), Yongquan Zheng (Автор), Huadong Deng (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Предметы: article
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It has been reported that drug-drug interactions (DDIs) can affect the pharmacokinetics and pharmacodynamics of various oral drugs. To better understand the effects of azole antifungal drugs (ketoconazole, fluconazole, and itraconazole) on pyrotinib's pharmacokinetics, DDIs between pyrotinib an...