The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice

The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice

Neural tube defects (NTDs) are among the common and severe birth defects with poorly understood etiology. Mutations in the Wnt co-receptor LRP6 are associated with NTDs in humans. Either gain-of-function (GOF) or loss-of-function (LOF) mutations of Lrp6 can cause NTDs in mice. NTDs in Lrp6-GOF mutan...

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Main Authors: Tianyu Zhao (Author), Moira McMahon (Author), Kurt Reynolds (Author), Subbroto Kumar Saha (Author), Arjun Stokes (Author), Chengji J. Zhou (Author)
Format: Book
Published: The Company of Biologists, 2022-06-01T00:00:00Z.
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