The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice

• Main Authors: Tianyu Zhao (Author), Moira McMahon (Author), Kurt Reynolds (Author), Subbroto Kumar Saha (Author), Arjun Stokes (Author), Chengji J. Zhou (Author)
• Formato: Livro
• Publicado em: The Company of Biologists, 2022-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Neural tube defects (NTDs) are among the common and severe birth defects with poorly understood etiology. Mutations in the Wnt co-receptor LRP6 are associated with NTDs in humans. Either gain-of-function (GOF) or loss-of-function (LOF) mutations of Lrp6 can cause NTDs in mice. NTDs in Lrp6-GOF mutan...