Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy

• 主要な著者: Jūratė Savickienė (著者), Sandra Baronaitė (著者), Aistė Zentelytė (著者), Gražina Treigytė (著者), Rūta Navakauskienė (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2016-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Human amniotic-fluid-derived mesenchymal stem cells (AF-MSCs) are interesting for their multilineage differentiation potential and wide range of therapeutic applications due to the ease of culture expansion. However, MSCs undergo replicative senescence. So far, the molecular mechanisms that underlie...