Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation

• 主要な著者: Tomonori KAMEDA (著者), Hideyuki NAKASHIMA (著者), Takumi TAKIZAWA (著者), Fumihito MIURA (著者), Takashi ITO (著者), Kinichi NAKASHIMA (著者), Takuya IMAMURA (著者)
• フォーマット: 図書
• 出版事項: The Society for Reproduction and Development, 2021-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Post-mitotic neurons do exhibit DNA methylation changes, contrary to the longstanding belief that the epigenetic pattern in terminally differentiated cells is essentially unchanged. While the mechanism and physiological significance of DNA demethylation in neurons have been extensively elucidated, t...