Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions

• Main Authors: Sumit K. Chaturvedi (Author), Arun Parupudi (Author), Kristian Juul-Madsen (Author), Ai Nguyen (Author), Thomas Vorup-Jensen (Author), Sonia Dragulin-Otto (Author), Huaying Zhao (Author), Reza Esfandiary (Author), Peter Schuck (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibodies are a class of biotherapeutics used for an increasing variety of disorders, including cancer, autoimmune, neurodegenerative, and viral diseases. Besides their antigen specificity, therapeutic use also mandates control of their solution interactions and colloidal properties in o...