A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

• Main Authors: Daniela Castanotto (Author), Xiaowei Zhang (Author), Jacqueline Rüger (Author), Jessica Alluin (Author), Ritin Sharma (Author), Patrick Pirrotte (Author), Lars Joenson (Author), Silvia Ioannou (Author), Michael S. Nelson (Author), Jonas Vikeså (Author), Bo Rode Hansen (Author), Troels Koch (Author), Mads Aaboe Jensen (Author), John J. Rossi (Author), Cy A. Stein (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The androgen receptor (AR) plays a critical role in the development of prostate cancer (PCa) through the activation of androgen-induced cellular proliferation genes. Thus, blocking AR-mediated transcriptional activation is expected to inhibit the growth and spread of PCa. Using tailor-made splice-sw...