Caudal-Rostral Progression of Alpha Motoneuron Degeneration in the SOD1^G93A Mouse Model of Amyotrophic Lateral Sclerosis

• Main Authors: Alastair J. Kirby (Author), Thomas Palmer (Author), Richard J. Mead (Author), Ronaldo M. Ichiyama (Author), Samit Chakrabarty (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mice with transgenic expression of human SOD1^G93A are a widely used model of ALS, with a caudal-rostral progression of motor impairment. Previous studies have quantified the progression of motoneuron (MN) degeneration based on size, even though alpha (α-) and gamma (γ-) MNs ov...