Optimization of Synthesis of the Amino Lipid ECO for Effective Delivery of Nucleic Acids

• Main Authors: Andrew L. Schilb (Author), Josef H. Scheidt (Author), Amita M. Vaidya (Author), Zhanhu Sun (Author), Da Sun (Author), Sangjoon Lee (Author), Zheng-Rong Lu (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleic acids are promising for a variety of therapies, such as cancer therapy and the gene therapy of genetic disorders. The therapeutic efficacy of nucleic acids is reliant on the ability of their efficient delivery to the cytosol of the target cells. Amino lipids have been developed to aid in the...