The first human epitope map of the alphaviral E1 and E2 proteins reveals a new E2 epitope with significant virus neutralizing activity.

• Main Authors: Ann R Hunt (Author), Shana Frederickson (Author), Toshiaki Maruyama (Author), John T Roehrig (Author), Carol D Blair (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Venezuelan equine encephalitis virus (VEEV) is responsible for VEE epidemics that occur in South and Central America and the U.S. The VEEV envelope contains two glycoproteins E1 (mediates cell membrane fusion) and E2 (binds receptor and elicits virus neutralizing antibodies). Previously we construct...