Discovery of inhibitors of protein tyrosine phosphatase 1B contained in a natural products library from Mexican medicinal plants and fungi using a combination of enzymatic and in silico methods**

• Main Authors: Miriam Díaz-Rojas (Author), Martin González-Andrade (Author), Rodrigo Aguayo-Ortiz (Author), Rogelio Rodríguez-Sotres (Author), Araceli Pérez-Vásquez (Author), Abraham Madariaga-Mazón (Author), Rachel Mata (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work aimed to discover protein tyrosine phosphatase 1B (PTP1B) inhibitors from a small molecule library of natural products (NPs) derived from selected Mexican medicinal plants and fungi to find new hits for developing antidiabetic drugs. The products showing similar IC50 values to ursolic acid...