Hypoxia-Inducible Factor-1α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae-Induced Pneumosepsis

• Main Authors: Natasja A. Otto (Author), Liza Pereverzeva (Author), Valentine Leopold (Author), Ivan Ramirez-Moral (Author), Joris J. T. H. Roelofs (Author), Jeroen W. J. van Heijst (Author), Alex F. de Vos (Author), Tom van der Poll (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia-inducible factor- (HIF-) 1α has been implicated in the ability of cells to adapt to alterations in oxygen levels. Bacterial stimuli can induce HIF1α in immune cells, including those of myeloid origin. We here determined the role of myeloid cell HIF1α in the host response during pneumonia and...