AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

• Main Authors: Hai B. Tran (Author), Rhys Hamon (Author), Hubertus Jersmann (Author), Miranda P. Ween (Author), Patrick Asare (Author), Rainer Haberberger (Author), Harshita Pant (Author), Sandra J. Hodge (Author)
• Format: Book
• Published: BMC, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction The role inflammasomes play in chronic obstructive pulmonary disease (COPD) is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of COPD patients, and in response to cigarette smoke. Methods Lung tissue, bronchoscopy-derived alveolar macrophages an...