A competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies

• Váldodahkkit: Zhengqi Zhang (Dahkki), Yuetian Yan (Dahkki), Shunhai Wang (Dahkki), Ning Li (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Therapeutic monoclonal antibodies (mAbs) have a propensity to host a large number of chemical and enzymatical modifications that need to be properly assessed for their potential impact on target binding. Traditional strategies of assessing the criticality of these attributes often involve a laboriou...