Could Postnatal Age-Related Uridine Diphosphate Glucuronic Acid Be a Rate‐Limiting Factor in the Metabolism of Morphine During the First Week of Life?

• Main Authors: Tao Liu (Author), Tamorah R. Lewis (Author), Jason N. Moore (Author), Walter K. Kraft (Author), Estelle B. Gauda (Author), David Sartori (Author), David E. Moody (Author), Jogarao V. S. Gobburu (Author), Vijay Ivaturi (Author)
• Format: Book
• Published: Wiley, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neonates experience dramatic changes in the disposition of drugs after birth as a result of enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrual age, and body weight as physiologically reasonable predicto...