PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis

• Main Authors: Weilong Hong (Author), Xue Zeng (Author), Houping Wang (Author), Xuxin Tan (Author), Yu Tian (Author), Hongtao Hu (Author), Milad Ashrafizadeh (Author), Gautam Sethi (Author), He Huang (Author), Chenyang Duan (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coronavirus disease 2019 (COVID-19) affected people worldwide, and fever is one of the major symptoms of this disease. Although Acetaminophen (APAP) is a common fever-reducing medication, it can also mediate liver injury. However, the role of PGC-1α in regulating mitochondrial quality control by lac...