Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome

• Egile Nagusiak: Lyndsey L. Anderson (Egilea), Michael Udoh (Egilea), Declan Everett-Morgan (Egilea), Marika Heblinski (Egilea), Iain S. McGregor (Egilea), Samuel D. Banister (Egilea), Jonathon C. Arnold (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2022-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Objective Cannabigerolic acid (CBGA), a precursor cannabinoid in Cannabis sativa, has recently been found to have anticonvulsant properties in the Scn1a +/- mouse model of Dravet syndrome. Poor brain penetration and chemical instability of CBGA limits its potential as an anticonvulsant ther...