Activation of PXR causes drug interactions with Paxlovid in transgenic mice

• Main Authors: Saifei Lei (Author), Alice Guo (Author), Jie Lu (Author), Qian Qi (Author), Aaron S. Devanathan (Author), Junjie Zhu (Author), Xiaochao Ma (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paxlovid is a nirmatrelvir (NMV) and ritonavir (RTV) co-packaged medication used for the treatment of coronavirus disease 2019 (COVID-19). The active component of Paxlovid is NMV and RTV is a pharmacokinetic booster. Our work aimed to investigate the drug/herb-drug interactions associated with Paxlo...