Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

• Main Authors: Jiaojie Wei (Author), Yang Long (Author), Rong Guo (Author), Xinlei Liu (Author), Xian Tang (Author), Jingdong Rao (Author), Sheng Yin (Author), Zhirong Zhang (Author), Man Li (Author), Qin He (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight heparin (LMWH)-d-α-tocopheryl succinate (TOS) micel...