Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight heparin (LMWH)-d-α-tocopheryl succinate (TOS) micel...

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Main Authors: Jiaojie Wei (Author), Yang Long (Author), Rong Guo (Author), Xinlei Liu (Author), Xian Tang (Author), Jingdong Rao (Author), Sheng Yin (Author), Zhirong Zhang (Author), Man Li (Author), Qin He (Author)
Formato: Livro
Publicado em: Elsevier, 2019-07-01T00:00:00Z.
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