In silico off-target profiling for enhanced drug safety assessment

• Main Authors: Jin Liu (Author), Yike Gui (Author), Jingxin Rao (Author), Jingjing Sun (Author), Gang Wang (Author), Qun Ren (Author), Ning Qu (Author), Buying Niu (Author), Zhiyi Chen (Author), Xia Sheng (Author), Yitian Wang (Author), Mingyue Zheng (Author), Xutong Li (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent phases. However, the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screening and animal testing is substantial. Drug off-targ...