Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives

• Main Authors: Aurore Tourville (Author), Sarah Viguier (Author), Florencia González-Lizárraga (Author), Rodrigo Hernán Tomas-Grau (Author), Paola Ramirez (Author), Jean-Michel Brunel (Author), Mauricio Dos Santos Pereira (Author), Elaine Del-Bel (Author), Rosana Chehin (Author), Laurent Ferrié (Author), Rita Raisman-Vozari (Author), Bruno Figadère (Author), Patrick Pierre Michel (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several studies have reported that the tetracycline (TC) class antibiotic doxycycline (<b>DOX</b>) is effective against Parkinson's disease (PD) pathomechanisms. The aim of the present work was three-fold: (i) Establish a model system to better characterize neuroprotection by <b&...