Novel evidence of CNV deletion in KCTD13 related to the severity of isolated hypospadias in Chinese population

• Main Authors: Yijing Chen (Author), Lijun Zhou (Author), Fang Chen (Author), Zhongzhong Chen (Author), Yichen Huang (Author), Yiqing Lv (Author), Min Wu (Author), Xiaoling Lin (Author), Hua Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundCNV in KCTD13 has been identified to influence androgen receptor function via its changes in gene dosage, which might contribute to hypospadias. However, there is lack of population-level evidence to assess the contribution of KCTD13 CNV to hypospadias.Methods349 isolated hypospadias patie...