Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites

• Main Authors: Ying Xu (Author), Yan Xia (Author), Qinhui Liu (Author), Xiandan Jing (Author), Qin Tang (Author), Jinhang Zhang (Author), Qingyi Jia (Author), Zijing Zhang (Author), Jiahui Li (Author), Jiahao Chen (Author), Yimin Xiong (Author), Yanping Li (Author), Jinhan He (Author)
• Format: Bog
• Udgivet: Elsevier, 2023-12-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Excessive N-acetyl-p-benzoquinone imine (NAPQI) formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen (APAP) overdose caused acute liver failure (ALF). S-glutathionylation is a reversible redox post-translational modification and a prospecti...