AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells

• Main Authors: Diana Rafael (Author), Petra Gener (Author), Fernanda Andrade (Author), Joaquin Seras-Franzoso (Author), Sara Montero (Author), Yolanda Fernández (Author), Manuel Hidalgo (Author), Diego Arango (Author), Joan Sayós (Author), Helena F. Florindo (Author), Ibane Abasolo (Author), Simó Schwartz (Author), Mafalda Videira (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC) are responsible of sustaining the metastatic spread of the disease to distal organs and the progressive gain of resistance of advanced cancers...