Modeling and Simulation as a Tool to Assess Voriconazole Exposure in the Central Nervous System

• Main Authors: Keli Jaqueline Staudt (Author), Bruna Bernar Dias (Author), Izabel Almeida Alves (Author), Bénédicte Lelièvre (Author), Jean-Philippe Bouchara (Author), Bibiana Verlindo de Araújo (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voriconazole is a triazole antifungal used empirically for the treatment of complicated meningitis associated with <i>Cryptococcus neoformans</i>. Biopsy studies show that the drug exhibits adequate brain penetration although levels of cerebral spinal fluid (CSF) are highly variable. Con...