Modeling and Simulation as a Tool to Assess Voriconazole Exposure in the Central Nervous System

• Príomhchruthaitheoirí: Keli Jaqueline Staudt (Údar), Bruna Bernar Dias (Údar), Izabel Almeida Alves (Údar), Bénédicte Lelièvre (Údar), Jean-Philippe Bouchara (Údar), Bibiana Verlindo de Araújo (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2023-06-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Voriconazole is a triazole antifungal used empirically for the treatment of complicated meningitis associated with <i>Cryptococcus neoformans</i>. Biopsy studies show that the drug exhibits adequate brain penetration although levels of cerebral spinal fluid (CSF) are highly variable. Con...