Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method

• Автори: Osamu Shibata (Автор), Kenya Kamimura (Автор), Yuto Tanaka (Автор), Kohei Ogawa (Автор), Takashi Owaki (Автор), Chiyumi Oda (Автор), Shinichi Morita (Автор), Atsushi Kimura (Автор), Hiroyuki Abe (Автор), Satoshi Ikarashi (Автор), Kazunao Hayashi (Автор), Takeshi Yokoo (Автор), Shuji Terai (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2022-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver human pancreatic cancer-related genes to the pancreas of wild-type rats. KRASG12D-induced pancreatic intraepithelial neoplasia lesions showed malignan...