Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method

• Main Authors: Osamu Shibata (Author), Kenya Kamimura (Author), Yuto Tanaka (Author), Kohei Ogawa (Author), Takashi Owaki (Author), Chiyumi Oda (Author), Shinichi Morita (Author), Atsushi Kimura (Author), Hiroyuki Abe (Author), Satoshi Ikarashi (Author), Kazunao Hayashi (Author), Takeshi Yokoo (Author), Shuji Terai (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver human pancreatic cancer-related genes to the pancreas of wild-type rats. KRASG12D-induced pancreatic intraepithelial neoplasia lesions showed malignan...