Tumor necrosis factor receptor associated factor 3 regulated the signaling pathway of STING/IFN-I for improving the lupus nephritis related podocyte injury and understanding its mechanism

• Main Authors: Jin-shu Chen (Author), Pi-hou Chen (Author), Yi-jin Song (Author), Jia-xin Wei (Author), Jing Sun (Author), Zhi-quan Xu (Author)
• Format: Book
• Published: Editorial Department of Journal of Clinical Nephrology, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective To explore the effect and mechanism of TRAF3 on IgG-induced apoptosis and inflammation of human podocyte cell (HPC). Methods HPC cells were cultured in vitro and induced with purified IgG from lupus nephritis (LN) patients to create an inflammatory environment for 24h. The cells were divid...