Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures

• Main Authors: Vivek Rai (Author), Daniel X. Quang (Author), Michael R. Erdos (Author), Darren A. Cusanovich (Author), Riza M. Daza (Author), Narisu Narisu (Author), Luli S. Zou (Author), John P. Didion (Author), Yuanfang Guan (Author), Jay Shendure (Author), Stephen C.J. Parker (Author), Francis S. Collins (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type 2 diabetes (T2D) is a complex disease characterized by pancreatic islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide association studies (GWAS) have identified > 400 independent signals that encode genetic predisposition. More than 90% of as...