Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation

• Main Authors: Linbin Zhou (Author), Bo Man Ho (Author), Hoi Ying Emily Chan (Author), Yan Tong (Author), Lin Du (Author), Jing Na He (Author), Danny Siu-Chun Ng (Author), Clement C. Tham (Author), Chi Pui Pang (Author), Wai Kit Chu (Author)
• Format: Book
• Published: Karger Publishers, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequent activation of the stimulator of interferon genes (STINGs). The cGAS-STING signaling has multiple...