Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators

• Main Authors: Jianglin Wang (Author), Xueyan Jiang (Author), Lixin Zhao (Author), Shengjia Zuo (Author), Xiantong Chen (Author), Lingmin Zhang (Author), Zhongxiao Lin (Author), Xiaoya Zhao (Author), Yuyan Qin (Author), Xinke Zhou (Author), Xi-Yong Yu (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpression of exogenous lineage-determining factors succeeds in directly reprogramming fibroblasts to various cell types. Several studies have reported reprogramming of fibroblasts into induced cardiac progenitor cells (iCPCs). CRISPR/Cas9-mediated gene activation is a potential approach for cel...