Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure

• Main Authors: Imad Kassem (Author), Steven Sanche (Author), Jun Li (Author), Guillaume Bonnefois (Author), Marie‐Pierre Dubé (Author), Jean‐Lucien Rouleau (Author), Jean‐Claude Tardif (Author), Michel White (Author), Jacques Turgeon (Author), Fahima Nekka (Author), Simon deDenus (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heart failure (HF) causes pathological changes in multiple organs, thus affecting the pharmacokinetics (PK) of drugs. The aim of this study was to investigate the PK of candesartan in patients with HF while examining significant covariates and their related impact on estimated clearance using a popu...