Blockade of neutrophil recruitment to tumor sites based on sialic acid-modified nanoplatforms enhances the efficacy of checkpoint blockade immunotherapy

• Main Authors: Meng Chen (Author), Zhaowei Qi (Author), Xianmin Meng (Author), Shuo Wang (Author), Xueying Zheng (Author), Miao Hu (Author), Xinrong Liu (Author), Yanzhi Song (Author), Yihui Deng (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Checkpoint inhibitors are designed to rejuvenate depleted or suppressed T cells in the tumor microenvironment, relying on the immune system to control and kill tumors. However, accumulating evidence indicates that tumor-infiltrating neutrophils impede the proliferation and activation of T cells and...