Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• Main Authors: María Ailén Natale (Author), Todd Minning (Author), María Cecilia Albareda (Author), Melisa Daiana Castro Eiro (Author), María Gabriela Álvarez (Author), Bruno Lococo (Author), Gonzalo Cesar (Author), Graciela Bertocchi (Author), María Josefina Elias (Author), María Belén Caputo (Author), Rick Lee Tarleton (Author), Susana Adriana Laucella (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...