Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• প্রধান লেখক: María Ailén Natale (লেখক), Todd Minning (লেখক), María Cecilia Albareda (লেখক), Melisa Daiana Castro Eiro (লেখক), María Gabriela Álvarez (লেখক), Bruno Lococo (লেখক), Gonzalo Cesar (লেখক), Graciela Bertocchi (লেখক), María Josefina Elias (লেখক), María Belén Caputo (লেখক), Rick Lee Tarleton (লেখক), Susana Adriana Laucella (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...